guitarpicker56
It is most usual to plug in an acoustic-electric into an acoustic amplifier to attain the acoustic feel and essence. On the other hand, plugging an acoustic into an amplifier used primarily for electric guitars will produce harsh and heavy tones possibly unlike what the artist may wish to hear. I use a Fender Acoustisonic amp for my acoustics and an old Woodson with a Zoom 504 foot switching mechanism to produce the different tones I need for my Gretsch Nashville. The answer? The type of amplifier makes the difference.

Nicholas W
An acoustic will sound so much nicer and cleaner when plugged in (if plugged into the right amp). Electric guitars just don't get the same sound when plugged in. However, I've always been a fan of just mic-ing the acoustic guitar through the PA to get the real sound. Nothing can beat the natural sound of an acoustic guitar.